Key scientific publications

GeNeuro's science is based on more than 25 years of research, performed internally and in collaboration with renowned academic groups.

Endogenous viruses: insights into viral evolution and impact on host biology

Feschotte C, Gilbert C

Nat Rev Genet. 2012, 13(4):283-96


The envelope protein of a human endogenous retrovirus-W family activates innate immunity through CD14/TLR4 and promotes Th1-like responses

Rolland A, Jouvin-Marche E, Viret C, Faure M, Perron H, Marche PN

J Immunol 2006, 176:7636-7644.


Human endogenous retrovirus (HERV)-W ENV and GAG proteins: physiological expression in human brain and pathophysiological modulation in multiple sclerosis lesions.
Perron H, Lazarini F, Ruprecht K, Pechoux-Longin C, Seilhean D, et al
J Neurovirol 2005, 11:23-33.

Correlation between disease severity and in vitro cytokine production mediated by MSRV (multiple sclerosis associated retroviral element) envelope protein in patients with multiple sclerosis.
Rolland A, Jouvin-Marche E, Saresella M, Ferrante P, Cavaretta R, Creange A, Marche P, Perron H
J Neuroimmunol 2005, 160:195-203

Multiple sclerosis-associated retrovirus particles cause T lymphocyte-dependent death with brain hemorrhage in humanized SCID mice model.
Firouzi R, Rolland A, Michel M, Jouvin-Marche E, Hauw JJ, et al
J Neurovirol 2003, 9:79-93.

Multiple sclerosis retrovirus particles and recombinant envelope trigger an abnormal immune response in vitro, by inducing polyclonal Vbeta16 T-lymphocyte activation.
Perron H, Jouvin-Marche E, Michel M, Ounanian-Paraz A, Camelo S, et al
Virology 2001, 287:321-332.

Detection of virion-associated MSRV-RNA in serum of patients with multiple sclerosis.
Garson JA, Tuke PW, Giraud P, Paranhos-Baccala G, Perron H
Lancet. 1998 Jan 3;351(9095):33.

Cell cultures and associated retroviruses in multiple sclerosis. Collaborative Research Group on MS.
Perron H, Firouzi R, Tuke P, Garson JA, Michel M, Beseme F, Bedin F, Mallet F, Marcel E, Seigneurin JM, Mandrand B
Acta Neurol Scand Suppl 1997, 169:22-31.

Molecular identification of a novel retrovirus repeatedly isolated from patients with multiple sclerosis. The Collaborative Research Group on Multiple Sclerosis.
Perron H, Garson JA, Bedin F, Beseme F, Paranhos-Baccala G, et al
Proc Natl Acad Sci U S A 1997, 94:7583-7588.

Herpes simplex virus ICP0 and ICP4 immediate early proteins strongly enhance expression of a retrovirus harboured by a leptomeningeal cell line from a patient with multiple sclerosis.
Perron H, Suh M, Lalande B, Gratacap B, Laurent A, Stoebner P, Seigneurin JM
. J Gen Virol 1993, 74:65-72.


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